A TDG/CBP/RARa Ternary Complex Mediates the Retinoic Acid-dependent Expression of DNA Methylation-sensitive Genes
نویسندگان
چکیده
1 Vaccine Research Institute, INSERM U955, Institut Mondor de Recherche Biomédicale, 94011 Créteil, France 2 Institut des Hautes Études Scientifiques, 91440 Bures sur Yvette, France 3 Unité de Glycobiologie Structurale et Fonctionnelle – CNRS UMR 8576, Group of NMR and Structural Biology, Université Lille 1, 59655 Villeneuve d’Ascq, France 4 Unité de Glycobiologie Structurale et Fonctionnelle – CNRS UMR 8576, Neuroplasticity Team, Université Lille 1, 59655 Villeneuve d’Ascq, France 5 CNRS UMR 7224, Université Pierre et Marie Curie, 75005 Paris, France
منابع مشابه
A TDG/CBP/RARα Ternary Complex Mediates the Retinoic Acid-dependent Expression of DNA Methylation-sensitive Genes
The thymine DNA glycosylase (TDG) is a multifunctional enzyme, which is essential for embryonic development. It mediates the base excision repair (BER) of G:T and G:U DNA mismatches arising from the deamination of 5-methyl cytosine (5-MeC) and cytosine, respectively. Recent studies have pointed at a role of TDG during the active demethylation of 5-MeC within CpG islands. TDG interacts with the ...
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تاریخ انتشار 2014